Hi man, Id use pregnenolone and D-phenylalanine to counter the long term sides. Hello. In short, being aware that finasteride may cause sexual side effects is associated with a higher risk of actually experiencing these side effects. Support inquiries will not be addressed. Can you recommend one? These serious adverse side effects include persistent or irreversible sexual, neurological, physical and mental side effects. If you have a northern European haplotype with a bad SNP profile and you get no or limited sunlight = no sulfated vitamin D3 = altered estradiol = altered testosterone = no progesterone = dehydration due to poor mitochondrial flux = no sex drive = no sex = no oxytocin = Tensegrity 7 blog. The https:// ensures that you are connecting to the If youre looking for something effective but dont want too many steps in your routine, this once-a-day pill could be right for you. Acta Derm Venereol. The Post-Finasteride Syndrome Foundation 2023, Support Program Connects PFS Patients Worldwide, Genetic and Rare Diseases Information Center, Persistent erectile dysfunction in men exposed to the 5-reductase inhibitors finasteride or dutasteride, Finasteride use in the male infertility population: effects on semen and hormone parameters, Single and repeated dose of finasteride topical solution in subjects with androgenetic alopecia. there is a big thread about the Aussie donut hole - where JK gave us tons of info. Did you check your estrogen before and after? HCG will most likely increase progesterone, but hopefully, it can stimulate 5AR which will increase allopregnanolone. Its available as a liquid and as a foam and is applied directly to the areas of your scalp affected by male pattern baldness. This is a difficult question to answer as there is a small minority of PFS patients who have reported anecdotally that they have developed PFS only after quitting finasteride. Topical progesterone the skin is rich in 5-AR, so applying progesterone to the skin should increase allopregnanolone. Practo Consult. Some people get results, but often only 1 steroid isnt enough. We offer a combination Topical Finasteride & Minoxidil Spray that allows you to get the benefits of finasteride and minoxidil in a single medication. I took a topical of Fin/Minoxidil for less than 3 months and just recently have experience whole body weakness, stiffness, joint pain, brain fog and a lower feeling of well-being/happiness. An adrenal gland problem that can cause anxiety disorders. Discussion in 'My Optimal Journal' started by JPB, Dec 31, 2018. Bookshelf Topical finasteride works at the scalp level rather than systemically, and research suggests its effective at treating hair loss. Are antidepressants safe for PFS patients? I have blood and hormones test results if u want. shrink penis. But future studies may involve patient testing. In 2013, Swiss pharmaceutical company Polichem SA conducted a study, published in the Journal of the American Academy of Dermatology and titled Single and repeated dose of finasteride topical solution in subjects with androgenetic alopecia, which showed that topical finasteride is absorbed and lowers serum DHT levels almost to the same degree as the oral medication. HCG will increase progesterone or will decrease it? Ive moved out of a city recently to an area with a low population. Below, weve shared methods that you can use to treat and prevent male pattern baldness while minimizing your risk of post-finasteride surgery. Yes TRT does seem to help people, but dont solve everything. (It is not known if PED in that subset ever subsided, or persisted.) Acufene The program can also connect the loved ones of PFS patients who have taken their own lives with the loved ones of other PFS patients who suffered the same fate. As a result of this, most medical bodies do not officially recognize post-finasteride syndrome as a medical condition. MeSH Now, this doesnt mean that finasteride itself cant cause side effects. In other words, the biological 8600 Rockville Pike What kind of doctor would be willing to help with something like this? Do you generally feel overstimulated and suffer from insomnia? Always talk to your doctor about the risks and benefits of any treatment. Twenty-six men with a history of 5ARI use reporting symptoms consistent with post-finasteride Post-finasteride syndrome is a term thats used to describe a range of persistent symptoms that occur in a small percentage of men who use the medication finasteride. PMC One way to treat your hair loss without using finasteride is to use non-prescription treatments for hair loss, such as minoxidil, hair loss shampoo and hair growth vitamins. Disproportionality analysis based on both the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) pharmacovigilance databases. If a pill feels like an overwhelming way to treat male pattern hair loss, this spray with finasteride & minoxidil could be for you. However, we may soon see more data. less*, without hair) is Reddit's most popular community for males and females coping with hair loss. A: Most likely, yes. According to the Post-Finasteride Syndrome Foundation, these may include: My hypothesis is that finasteride can cause brain damage which needs to be reversed. If youve already done blood tests and want to learn how to interpret them, check out these articles: If DHT is high, then you dont have to focus on boosting DHT, but maybe rather allopregnanolone through increasing 5-AR type 1. I suffered PFS till 4 years with many problems: Unlike regular finasteride side effects, post-finasteride syndrome is designed as persistent side effects from finasteride that can continue after the medication is discontinued. Here we evaluate the scientific and clinical evidence in the contemporary medical literature to address the very fundamental question: Is PFS a real clinical condition caused by finasteride use or are the reported symptoms only incidentally associated with but not caused by finasteride use? On the other hand, there are reports of people developing PFS within a few days of stopping finasteride. Like finasteride, dutasteride (brand name Adovart) is a 5-alpha-reductase inhibitor that has a similar chemical composition. Hi, being a young guy with PFS since 8 months this article has been very helpful to furthermore understand what is possibly going on, so thank you. Although, they would like you to believe testosterone replacement is the only solution to make a full recovery. This would suggest that tapering might be a safer approach. Im wondering if that Has to do with gut health. Finally, weve explained your options for treating and preventing hair loss if youre worried about developing post-finasteride syndrome. How can I do that? Published by Elsevier Inc. All rights reserved. However, it does raise questions about the theory that finasteride has the potential to cause lasting, long-term, severe side effects. It was described that the prolonged use of 5-steroid reductase inhibitors in patients with alopecia can cause persistent side effects called a post-finasteride syndrome (PFS), that is not just a simple coexistence of events, but rather a definite syndrome with an iatrogenic background. So far I tread Clomid and nolvadex cycles but I only had one day where libido returned, rest of time didnt feel anything good or bad when on it. According to the Post-Finasteride Syndrome Foundation, a 501(c)(3) nonprofit corporation thats dedicated to raising funds for research into post-finasteride syndrome, men with post-finasteride syndrome have reported the following physical symptoms: Sexual dysfunction, including a decreased sex drive or complete loss of libido, Loss of morning wood and spontaneous erections, Peyronie's disease (growth of scar tissue in the penis), Sexual anhedonia, or loss of pleasure from sexual stimulation and/or arousal, Ejaculation disorders, such as reduced ejaculatory volume and force, Gynecomastia, or male breast growth and sensitivity, Chronic fatigue and lack of energy and enthusiasm, Muscle pain, weakness, cramps, stiffness and twitching, Rhabdomyolysis (rapid breakdown of damaged or injured skeletal muscle), Dry, thinning skin and decreased production of sebum (an oily substance that products your skin), Melasma (a skin condition that involves patches of dark, discolored skin), Lipoatrophy (loss of fat tissue in specific areas of the body), Increased body mass index (BMI) and fat deposition, Reduced HDL cholesterol levels, raised triglycerides and fasting glucose, Increased rheumatoid factor (proteins produced by the immune system), Optic neuropathy (damage to the optic nerve inside the eyes), Ocular toxicity (drug-induced damage to the eyes). Practo Health Feed. Etc Etc Therefore, we recommend caution and discussion with your physician about the potential risks before deciding to treat it with SSRIs. Thanks. I haven't tried Fens, but relate to the brainfog and depression and no morning wood or it getting spontaneously glorious. All my symptoms have subsided and improved with this Chronic insomnia , I am now taking Trazodone which helps me get to sleep, I also have myoclonic twitches and brain zaps while trying to fall asleep and my auditory system is super sensitive any small noise at night makes my me jump even when wearing ear plugs. More and more, doctors who do so wind up contacting the foundation directly to inquire further about the condition. Other patients report that they become more stable and learn to better cope with the condition over a period of one to three years, rather than return to full health. Press question mark to learn the rest of the keyboard shortcuts. In theory, the effects could be additive, but it is not known if the added effects would be beneficial or harmful. Use Catuaba bark extract, mucuna pruriens, Tribulus Terrestris, etc. If I can increase my DHT levels again by upping my TRT and take an estrogen blocker (blood levels were elevated) with regular workouts how long do you think it would take to return to normal? Book Full Body Checkups. However, its still possible to take action and reduce the severity of your hair loss without using finasteride. Then he/she implied that its probably all in my head. Hi Ben, thanks for reaching out. Federal government websites often end in .gov or .mil. Bone pain However, the PFS Foundation strongly discourages the use of finasteride for hair loss by anyone. ARE THE SEXUAL SIDE EFFECTS WORTH THICK HAIR? This is understandably concerning for many men with male pattern baldness or benign prostatic hyperplasia who are considering finasteride as a treatment. 5-R type 1, which creates the neurosteroids 5-DHP and allopregnanolone downregulate the glutamatergic system. Finasteride is a 5-alpha reductase inhibitor thats used to treat androgenetic alopecia (a clinical term for male pattern baldness) and benign prostatic hyperplasia (non-cancerous growth of the prostate gland). Sex Med. I definitely feel ten years younger!, In just as little over two and half months, I can really see the difference in thickness and in color., 4-months strong and my confidence boosted back up to 100% using Hims, future me really does thank me., Im a 34 year old father of two and have been using Hims for over a year now. Doses have ranged between 1200mg and 3600mg per day without significant side effects. FOIA sharing sensitive information, make sure youre on a federal Individual results will vary. No libido is a recovery really possible? Customers were given free product.. https://www.ncbi.nlm.nih.gov/books/NBK513329/, https://www.niddk.nih.gov/health-information/urologic-diseases/prostate-problems/prostate-enlargement-benign-prostatic-hyperplasia, https://www.pfsfoundation.org/about-pfs-post-finasteride-syndrome/, https://www.pfsfoundation.org/frequently-asked-questions/, https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/020788s028lbl.pdf, https://www.karger.com/Article/Fulltext/497362, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401955/, https://pubmed.ncbi.nlm.nih.gov/17655657/, https://pubmed.ncbi.nlm.nih.gov/27662439/, https://medlineplus.gov/genetics/condition/androgenetic-alopecia/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540144/, https://www.ncbi.nlm.nih.gov/books/NBK482378/, https://www.scitcentral.com/article/19/60/Randomized-Comparative-Research-Study-of-Topical-and-Oral-Finasteride-with-Minoxidil-for-Male-Pattern-Androgenetic-Alopecia-in-Indian-Patients, https://www.ijord.com/index.php/ijord/article/view/394, https://rarediseases.info.nih.gov/diseases/12407/adverse-events-of-5-alpha-reductase-inhibitors, many vitamins are vital for proper hair growth. Do explosive exercises, such as uphill sprints, muscle-ups, jump squats, burpees, etc. Any other advice that would help is greatly appreciated. 2022 Oct 26;12(11):1567. doi: 10.3390/biom12111567. We offer minoxidil liquid and minoxidil foam online. Thanks in advance. The other side effects, such as ejaculation disorder, breast enlargement and breast tenderness, were only reported by 0.1 percent of men who received the non-therapeutic placebo. Wider recognition of PFS symptoms, its incidence, course, prevention, and treatment possibilities will allow the indications for drug use to be reconsidered and treatment to be more personalized. The site is secure. Anecdotally, many PFS patients report that their sexual symptoms gradually increase in severity over time while taking finasteride. What do you think about a PCT strategy to see if that helps? So lets discuss what the drug, finasteride, does in the first place. The best way to connect with these patients is to participate in our Patient Support program. Post-finasteride syndrome is a term thats used to refer to a range of symptoms associated with the use of finasteride as a treatment for hair loss and benign prostatic hyperplasia. This site needs JavaScript to work properly. Rzeszotek S, Kolasa A, Pilutin A, Misiakiewicz-Has K, Sielatycka K, Wiszniewska B. Biomedicines. In the meantime, we are working hard to publish as much medical literature and other news about the condition as possible on our website. If you have any problems completing this registration, please email support@jackkruse.com and we will assist you. Q7: Are there any cases of PFS patients whove gotten 100% better? ***POST FINASTERIDE SYNDROME CAN LAST 3 MONTHS or PERMANENTLY. This is especially true once the placebo and nocebo effects are taken into consideration. Results: At the examination, the three postfinasteride patients reported muscular stiffness, cramps, tremors, and chronic fatigue in the absence of clinical evidence of any muscular disorder or strength reduction. WebDr Jordan Grant and Gil T talk about Post Finasteride Syndrome Recovery (PFS recovery). Learn how your comment data is processed. But we hope that in the coming years, clinical research will demonstrate precisely that. When you send us your Patient Support form, include a note in your email letting us know youd specifically like to connect with fellow PFS patients who are willing to share their coping strategies. Clipboard, Search History, and several other advanced features are temporarily unavailable. If youve searched online for information about these side effects, you may have come across mentions of long-lasting, persistent issues that are referred to as post-finasteride syndrome, or PFS. Although finasteride can cause adverse effects, there currently isnt any high quality evidence to show that these continue over the long term. Clipboard, Search History, and several other advanced features are temporarily unavailable. This is a difficult question to answer as there is a small minority of PFS patients who have reported anecdotally that they have developed PFS only after quitting finasteride. Other PFS patients anecdotally report PFS symptoms while using finasteride that get worse after quitting the drug. Would you like email updates of new search results? Since testosterone is an important hormone for sexual desire and function, this could cause a reduction in libido. This condition, termed post-finasteride syndrome (PFS) is characterized by sexual side effects (i.e., low libido, erectile dysfunction, decreased arousal and difficulty in However, there have been no published medical studies that report on the effectiveness of SSRIs to treat PFS. Gonadorelin vs HCG: which is best for TRT? more https://www.jasonemermd.com/cosmetic-dermatology/regenerative-medicine/hormonal With that in mind, DHT can take anywhere from4 weeks to 2 years or more to recover(R). Research has shown that finasteride cuts DHT levels in the prostate by upwards of 90 percent, and by more than 70 percent in the bloodstream. A similar trend occurred in trials of Proscar, a 5mg form of finasteride thats used to treat benign prostatic hyperplasia. 8600 Rockville Pike Additionally, although the drug is eliminated from the blood relatively quickly (half-life 4.8 to 6 hours), it remains active for much longer because it irreversibly binds to (and blocks the normal functioning of) the target enzyme 5-alpha-reductase (half-life 30 days). Its also worth noting that in practice, most hair transplantation surgery patients are treated with finasteride before and after the procedure. Unlike finasteride, you dont need a doctors prescription to purchase and use this medication. A: At the moment, theres no known test for determining whether any finasteride patient will develop PFS. HCG increased my anxiety. Hair transplant surgery provides permanent results, but it can be costly. Finasteride blocks the glutathione production leading to mycotoxin build up if you were living or working near mould and not knowing it. Dutasteride was the second inhibitor to be approved and has a similar safety profile. Sexual dysfunction; depression; erectile dysfunction; loss of libido; suicidal ideation. WebFinasteride is a 5-reductase enzyme inhibitor that has been approved for the treatment of male androgenic alopecia since 1997. An official website of the United States government. A second factor that may explain the symptoms of post-finasteride syndrome is existing mental illness. Federal government websites often end in .gov or .mil. Finasteride; adverse events; alopecia; benign prostate hyperplasia; dutasteride; erectile disorder; libido; post-finasteride syndrome. Q13: I understand we dont know which is riskier, quitting finasteride or staying on it, but I still want to quit. Several different methods are used in hair transplant surgery, including follicular unit extraction (FUE) and follicular unit transplantation (FUT). J Urol. There are some nice recovery stories on TR. Before Web30 yrs old Male asked about Post finasteride syndrome, 5 doctors answered this and 206 people found it useful. These customers results have not been independently verified. Palmitoylethanolamide (PEA) is a substance naturally produced in many cell types in our bodies, including in very high concentrations in our brains. Epub 2020 Sep 19. Are finasteride-related penile curvature/Peyronie's disease Adverse Event Reports worthy of further clinical investigation? I look and feel so much younger!, When I show my barber my progress, he is always in disbelief. A few of the best ways to lower prolactin include: For more a comprehensive guide on lowering prolactin, check out this article: Serotonin is most often high in all mental and physical disorders and there is always a serotonin receptor/s gone rogue. But check your bilirubin just in case. 200 mg of pregnenalone per day. The men that received the placebo reported similar side effects: 3.7 percent of men who received the placebo reported erectile dysfunction, 3.4 percent of men who received the placebo reported decreased libido, 0.8 percent of men who received the placebo reported decreased ejaculatory volume. government site. As I read websites like yours and CDsNuts. However, it can shift hair follicles into the anagen, or growth, phase of the hair growth cycle, which stimulates growth. government site. Our Support staff will manually approve your account within 24 hours, and you will get a notification. In some people with PFS, DHT might be normal, but testosterone and cortisol low and estrogen and prolactin high. I am investigating other solutions. Have you tried getting loads of sunlight? It scrambles your hormones, libido and cognition all over the place, right into the gutters, and leaves you feeling like an empty dysfunctional husk. Oral testosterone: Hows the best way to take it? Outcomes after discontinuation of finasteride Dysfunctions If you stop with fin, then DHT should be back to normal in about 1-2 weeks (tissue binding lasts 4-5 days). The same pattern occurred with decreased libido, with 2.6 percent of finasteride users and 2.6 percent of placebo users both reporting this side effect. Answer: Hormonal optimization while on finesteride there are many options including peptides, and HCG as well as clomid/arimidex. Its really not the serotonin thats so beneficial. I have had PFS for 15 years, just came across your article, would you be interested in looking at my labs for comment? Cheers. The information contained herein is not a substitute for and should never be relied upon for professional medical advice. Finasteride was the first on the market and is currently the most widely used inhibitor. 2019 Jan 1;99(1):12-17. doi: 10.2340/00015555-3035. WebFinasteride has been used to shrink prostate and prevent male pattern baldness. You must log in or register to reply here. They report very high stress symptoms, which often develops into an episode of panic attack or anxiety attack. After using finasteride at a 5mg daily dose for one year, men reported the following side effects: Erectile dysfunction (reported by 8.1 percent of men), Decreased ilbido (reported by 6.4 percent of men), Decreased ejaculatory volume (reported by 3.7 percent of men), Ejaculation disorder (reported by 0.8 percent of men), Gynecomastia, or male breast enlargement (reported by 0.5 percent of men), Breast tenderness (reported by 0.4 percent of men). With proper testing you know where to focus on. It also improves blood flow to the scalp, which may help to supply your hair follicles with extra nutrients. Q3: Why do some finasteride patients develop PFS while others never seem to have any problems with the drug? Berrima in the Southern Highlands in NSW, its a beautiful area. PFS occurs in susceptible individuals even after small doses of the drug and can last for a long time after the discontinuation of treatment. Several studies over the past decade, for example, from Dokras,[], Illustration by Marta Pucci. Like in the above trial, men placed in the control group received a non-therapeutic placebo. I had no noticeable sides until sexual problems which started 3 weeks ago so I stopped. My biggest issue is low/no libido. I want to try a solution like HCG low dose: The treatment worked miraculously well and within a few months I was But the PFS Foundation is working as fast as possible to facilitate research that promises to identify the underlying biological mechanisms of PFS while laying the groundwork for the identification or development of effective therapies. synthesis of bile (5-R specifically), which is essential for the digestion of fat and absorption of fat-soluble vitamins. You are using an out of date browser. Kaplan-Marans E, Sandozi A, Martinez M, Lee J, Schulman A, Khurgin J. This reduction in DHT greatly reduces prostate growth and either slows down, stops or reverses hair loss caused by male pattern baldness. Unauthorized use of these marks is strictly prohibited. Please enable it to take advantage of the complete set of features! Could this cause any bad results that you can think of? Thanks for reaching out. I would appreciate some specific help if you could get back to me. Most of the research used to support the idea of post-finasteride syndrome is low quality, with issues such as selection bias believed to affect results. I think he would suggest you "train" your skin to absorb more UV buy doing that yeah. HHS Vulnerability Disclosure, Help Unfortunately, a small minority of patients report increasing severity of symptoms over time, especially with respect to some of the psychological side effects. Bile also acts as an anti-bacterial and anti-microbial substance which keeps the gut clean and prevents SIBO and SIFO. If so, well reach out to our entire PFS patient population to let you know and to provide you with participation parameters. Memory, libido, focus, drive, and sociability have all dramatically improved. really have been feeling like an empty husk like described lately, almost like a part of me was ripped out, but maybe one day i can find it again. You can argue with the theoretician but you cant argue with the anecdotal stories of successful recovery. Schifano N, Capogrosso P, Boeri L, Fallara G, Chiappini S, Rewhorn M, Cakir OO, Harvey H, Castiglione F, Alnajjar HM, Muneer A, Deho' F, Schifano F, Montorsi F, Salonia A. Int J Impot Res. For doctors. This is a psychological phenomenon in which a persons negative expectations about a specific medication or procedure may cause them to experience a negative symptom. This was a single center, prospective case-control study taking place between March 2013 and September 2018. Sexual Problems of Men With Androgenic Alopecia Treated With 5-Alpha Reductase Inhibitors. It has a population of 666. Some men with PFS report symptoms that last for years after stopping finasteride. From 50UI per day. Although a very small percentage of men claim to develop post-finasteride syndrome symptoms after taking finasteride, PFS isnt officially recognized by most of the medical community. Avoid all environmental plastics and toxins, Cold and hot exposure, such as swimming in a cold river and doing sauna sessions. Post-finasteride syndrome is leaving behind a slew of victims in its trail. wow very helpful articular and explains my symptoms exactly. Furthermore, finasteride inhibits CYP3A4 (which is the enzymes that detox finasteride) and that can cause a significant buildup of finasteride in the body over time. Post-finasteride syndrome is also said to involve mental and neurological symptoms. Like clomid, nolvadex, HCG? This site needs JavaScript to work properly. The https:// ensures that you are connecting to the An official website of the United States government. Unfortunately, there have also been no published medical studies that report on the effectiveness of other antidepressants in the treatment of depression associated with PFS. Hi David, Post-finasteride syndrome is characterized One key indisputable clinical evidence noted in all reported studies with finasteride and dutasteride was that use of these drugs is associated with development of sexual dysfunction, which may persist in a subset of men, irrespective of age, drug dose or duration of study. Now two months after stopping Dudasteride, my twitches and brain zaps are now greatly diminshed, insomnia is still a problem though. This is to prevent the many spam account signups which we receive on a daily basis. This issue can have a serious impact on a persons risk of experiencing side effects after taking medication, as healthcare providers are required to inform their patients about the potential side effects of medication as part of the treatment process. Careers. The .gov means its official. Among the men who used the placebo, 5.1 percent also reported experiencing erectile dysfunction. Thank you so much for your time. WebRecovered from Post Finasteride Syndrome! So thankful to have found this article. 30 mg/kg doses have been studied in children. But always do blood tests first to see what is really going on. Bone pain We rely on peer-reviewed studies, academic research institutions, and medical associations. Additional side effects of finasteride include: A low DHT state can lead to low dopamine (R), high estrogen (R), high prolactin (due to reduced dopamine), high cortisol (due to reduced clearance) (R), elevated serotonin (due to elevated estrogen and lower dopamine) and hypothyroidism (R). The treatment consists of taking large doses of B6 and Zinc, along with a few antioxidants. My total t is 650 ng/dl. A few good ways to lower serotonin include: For a more comprehensive guide on lowering serotonin, check out this article: Apart from just focusing on hormones and neurotransmitters, you can also focus on diet and lifestyle. Q6: How long before an effective treatment for PFS is developed? However, many men who were treated with a placebo medication also reported the same side effects: 1.3 percent of men who received the placebo reported decreased libido, 0.7 percent of men who received the placebo reported erectile dysfunction, 0.7 percent of men who received the placebo reported ejaculation disorder. Here is how you focus specifically on increasing allopregnanolone: The optimal range for estrogen is around 20pg/ml and if yours is much higher, it would be best to make it a priority to lower it. and transmitted securely. It can and does, although they typically arent common. Dopamine agonists, such as mucuna pruriens, huperzine A, Catuaba bark extract, etc. Over time, it has been considered a safe and well
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